2'3'-cGAMP (sodium salt)
2'3'-cGAMP (sodium salt) (CAS 1441190-66-4) is an endogenous cyclic dinucleotide second messenger produced by mammalian cyclic GMP-AMP synthase (cGAS) upon detection of cytosolic double-stranded DNA. It exerts its biological effect by directly binding and activating the protein STING (stimulator of interferon genes), thus triggering downstream signaling pathways involving TBK1 and IRF3, leading to type I interferon (IFN-β) induction. With a high affinity (Kd = 3.79 nM), superior to other cyclic dinucleotides, it serves as an essential tool for studying STING-mediated innate immune response and screening STING-targeted compounds.
References:
Zhang X. et al., 2013. Cyclic GMP-AMP containing mixed phosphdiester linkages is an endogenous high-affinity ligand for STING. Mol Cell.51(2):226-35.
Samira Khiar et al., 2017. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Sci Rep, 7 (1), 2561
Zhong B. et al., 2008. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity. 29(4):538-50.
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- 2. Huanling Zhang, Zining Wang, et al. "Endothelial STING-JAK1 interaction promotes tumor vasculature normalization and antitumor immunity." J Clin Invest. 2025 Jan 16;135(2):e180622 PMID: 39817453
- 3. Zhaofei Guo, Chenqi Guo, et al. "Antigens and adjuvants co-stabilized Pickering emulsions amplify immune responses of subunit vaccines." J Control Release. 2025 Jan 9:379:177-190 PMID: 39788375
- 4. Yu Deng, Quentin Hahn, et al. "2′ 3′-cGAMP interactome identifies 2′ 3′-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity" Sci Adv. 2024 Oct 18;10(42):eado7024. PMID: 39413198
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- 8. Bingbing Li, Lixia Xu, et al. "Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway." Cell Mol Neurobiol. 2024 Apr 18;44(1):36. PMID: 38637346
- 9. Yu An, Jinchao Zhu, et al. "Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS‐STING Signaling." Adv Sci (Weinh). 2024 May;11(20):e2308131. PMID: 38498770
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Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 718.37 |
Cas No. | 1441190-66-4 |
Formula | C20H22N10Na2O13P2 |
Synonyms | Guanosine-Adenosine 2',3'-cyclic monophosphate,2'-3'-Cyclic GMP-AMP |
Solubility | insoluble in EtOH; insoluble in DMSO; ≥7.56 mg/mL in H2O |
Chemical Name | adenylyl-(3'→5')-2'-guanylic acid, cyclic nucleotide, disodium salt |
SDF | Download SDF |
Canonical SMILES | O=P1([O-])O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)([O-])=O.[Na+].[Na+] |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure

Related Biological Data

Related Biological Data
