MSA-2
Catalog No.
B8469
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MSA-2 (CAS 129425-81-6) is an orally bioavailable, non-nucleotide agonist of stimulator of interferon genes (STING), functioning by binding STING as a non-covalent dimer with nanomolar affinity. It activates human STING isoforms WT and HAQ, demonstrating EC50 values of 8.3 μM and 24 μM, respectively. In murine tumor models, MSA-2 promotes interferon-β secretion, induces tumor regression, and facilitates sustained anti-tumor immune responses. Additionally, MSA-2 exhibits synergistic anti-tumor efficacy when combined with anti-PD-1 therapy, making it valuable for oncology research.
| Storage | Store at -20°C |
| M.Wt | 294.32 |
| Cas No. | 129425-81-6 |
| Formula | C14H14O5S |
| Solubility | Soluble in DMSO |
| Chemical Name | 4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C(CCC(O)=O)C1=CC2=CC(OC)=C(OC)C=C2S1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
