SR-717
Catalog No.
B8463
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SR-717 (CAS 2375421-09-1) is a non-nucleoside stimulator of interferon genes (STING) agonist structurally related to cyclic GMP–AMP (cGAMP). It activates innate immunity by inducing interferon-stimulated gene (ISG) expression through STING signaling. In cellular assays using wild-type and cGAS-knockout THP1 cell lines, SR-717 demonstrated EC50 values of 2.1 μM and 2.2 μM, respectively. Given its mechanism of STING activation, SR-717 serves as a valuable tool for research in cancer biology and immune regulation.
| Storage | Store at -20°C |
| M.Wt | 351.19 |
| Cas No. | 2375421-09-1 |
| Formula | C15H8F2LiN5O3 |
| Solubility | ≥4.87 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH |
| Chemical Name | lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate |
| SDF | Download SDF |
| Canonical SMILES | [O-]C(c(c(NC(c(cc1)nnc1-[n]1cncc1)=O)c1)cc(F)c1F)=O.[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
