H-151

H-151 (CAS No.: 941987-60-6) is a potent, selective, and covalent antagonist of the stimulator of interferon genes (STING) pathway, widely utilized as a small-molecule immunomodulator in innate immunity and inflammation research. Mechanistically, H-151 irreversibly interacts with STING, leading to suppression of downstream signaling events, including inhibition of TANK-binding kinase 1 (TBK1) phosphorylation and reduction of STING palmitoylation, thereby attenuating type I interferon responses and proinflammatory cytokine production. In cellular and in vivo models, H-151 has demonstrated robust inhibitory activity, effectively decreasing levels of interferon-β and interleukin-6 induced by STING activation, with functional effects typically observed in the nanomolar to low micromolar range depending on the assay system. This compound is broadly applied in studies investigating the molecular mechanisms of STING-mediated signaling, host defense, and autoinflammatory disease pathogenesis, as well as in pharmacological validation of STING as a therapeutic target. Experimental usage commonly involves treatment of immune or reporter cell lines and administration in animal models to evaluate pathway modulation, with concentrations or doses adjusted according to specific experimental objectives.