Taurodeoxycholic acid
Taurodeoxycholic acid is an anionic detergent related to bile salts, formed by the coupling of deoxycholic acid and Taurine in the liver. Its structure contains taurine amide bonds and it has both liposolubility and strong polarity. As a commonly used membrane protein separation reagent, its anionic property can destroy the lipid bilayer of the cell membrane, efficiently dissolve hydrophobic membrane proteins such as mitochondrial inner membrane proteins, and cause less damage to the protein structure. It is suitable for protein extraction in mitochondrial function research. In addition, this compound has anti-inflammatory and neuroprotective effects: by inhibiting the release of pro-inflammatory factors and regulating the activation of microglia, it alleviates the inflammatory response in the central nervous system. In neurodegenerative disease models, neuronal function can be protected by stabilizing mitochondrial membrane potential and inhibiting apoptosis.
| Physical Appearance | A solid |
| Storage | Store at -20°C for 3 years. |
| M.Wt | 499.7 |
| Cas No. | 516-50-7 |
| Formula | C26H45NO6S |
| Solubility | ≥53.4 mg/mL in DMSO; insoluble in EtOH; ≥51.7 mg/mL in H2O |
| Chemical Name | 2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(O)(=O)=O)=O)([H])C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
