taurochenodeoxycholate

taurochenodeoxycholate (CAS No.: 516-35-8) is a taurine-conjugated bile acid derived from chenodeoxycholic acid and represents a key endogenous component of bile with important roles in lipid digestion and hepatobiliary physiology. It functions primarily as a biological surfactant that facilitates the emulsification and absorption of dietary lipids, while also contributing to the regulation of cholesterol homeostasis through modulation of hepatic synthesis and secretion pathways. In addition to its metabolic roles, taurochenodeoxycholate has been shown to influence multiple cellular processes, including apoptosis, inflammation, and immune regulation, with evidence suggesting involvement in bile acid–activated signaling pathways such as farnesoid X receptor and membrane-associated receptors. Altered levels of this conjugated bile acid have been observed in pathological conditions including liver cirrhosis and cholangiocarcinoma, highlighting its relevance as a biomarker and a tool compound in disease modeling. In vitro studies indicate that its biological effects, including pro-apoptotic and anti-inflammatory activities, typically occur within the nanomolar to micromolar range depending on the cellular context. Consequently, taurochenodeoxycholate is widely utilized in biomedical research for investigating bile acid signaling, liver function, metabolic disorders, and cancer biology, as well as in analytical applications requiring precise quantification of bile acid profiles, with experimental concentrations tailored to specific assay systems and research objectives.