Maresin 1

Maresin 1 (CAS No.: 1268720-28-0) is a specialized pro-resolving lipid mediator biosynthesized by macrophages from the ω-3 fatty acid docosahexaenoic acid (DHA), belonging to a class of endogenous molecules that actively orchestrate the resolution phase of inflammation. It exerts potent anti-inflammatory and pro-resolving effects by modulating innate immune cell function, including inhibition of neutrophil adhesion and infiltration, reduction of pro-inflammatory cytokine production, and attenuation of oxidative stress such as decreased reactive oxygen species generation in vascular cells. Mechanistically, Maresin 1 is associated with activation of intracellular signaling pathways that elevate cytosolic calcium levels and promote secretion processes, contributing to its immunoregulatory functions. In vivo, it has demonstrated efficacy in reducing tissue injury and inflammatory responses in models of endotoxin-induced lung injury, dextran sulfate-induced colitis, and zymosan-induced peritonitis, indicating broad activity across inflammatory disease models. Its biological activity is typically observed in the nanomolar concentration range in vitro and at low microgram or nanogram dosing levels in animal studies, although effective concentrations and dosing regimens depend on experimental design. Detected in human inflammatory environments such as synovial fluid, Maresin 1 is widely used in studies of inflammation resolution, immune modulation, and related therapeutic target discovery in drug development and translational research.