Forsythin

Forsythin (CAS No.: 487-41-2) is a major active lignan extracted from the fruit of the traditional Chinese medicinal herb Forsythia suspensa, and it exhibits notable antioxidant, antibacterial, and anti-inflammatory properties. Studies indicate that Forsythin exerts multi-target anti-inflammatory effects by inhibiting key pro-inflammatory signaling pathways such as NF-κB and MAPK, as well as the NLRP3 inflammasome. In in vitro experiments, Forsythin shows low-micromolar activity across multiple inflammation models. In cellular and animal models, Forsythin has been used to evaluate its therapeutic potential in inflammatory diseases such as acute lung injury, arthritis, and colitis. The doses or concentrations used in experiments typically depend on the experimental design and research objectives. In addition, Forsythin shows protective effects on important organs such as the heart, liver, and kidneys in chronic metabolic and cardiovascular diseases. Animal studies and early clinical trials indicate that Forsythin has good safety, with only mild and transient adverse reactions reported.