Catalpol
Catalpol (CAS 2415-24-9) is an iridoid glycoside compound, primarily isolated from the roots of Rehmannia glutinosa and several other medicinal plants. Functioning as a neuroprotective and anti-inflammatory agent in neuronal and immune cells, it also exhibits antioxidant activity in various tissues. Additionally, Catalpol demonstrates hypoglycemic and cytoprotective properties through the modulation of multiple cellular pathways.
In neuropharmacological studies, Catalpol has been shown to protect against neurotoxicity with an EC50 of , tested against primary cultured neurons and microglial cell lines. It can also reduce the production of pro-inflammatory cytokines and inhibit apoptosis in neuronal cells by regulating the expression of key signaling molecules such as.
In diabetic models, Catalpol is widely used for investigating its hypoglycemic and potential antidiabetic effects. The compound has demonstrated efficacy in lowering blood glucose levels and improving insulin sensitivity in experimental in vivo systems. Furthermore, its application extends to studies of its anti-cancer, anti-oxidative, and anti-convulsant effects in various cell-based and in vivo models. Catalpol continues to be a valuable research tool in the fields of neuroprotection, metabolic disease, and inflammation.
| Storage | Store at -20°C |
| M.Wt | 362.33 |
| Cas No. | 2415-24-9 |
| Formula | C15H22O10 |
| Synonyms | Catalpinoside, Digitalis purpurea L |
| Solubility | ≥17.47 mg/mL in EtOH with ultrasonic; ≥22.7 mg/mL in DMSO; ≥25.25 mg/mL in H2O |
| Chemical Name | (2S,3R,4S,5S,6R)-2-[[(1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-2-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| SDF | Download SDF |
| Canonical SMILES | OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1O[C@@H]1OC=C[C@@H]2[C@H]1[C@@]1(CO)O[C@H]1[C@H]2O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
