Taurodeoxycholic Acid (sodium salt)

Taurodeoxycholic Acid (sodium salt) (CAS No.: 1180-95-6) is a bile salt-derived anionic detergent generated in the liver through conjugation of deoxycholic acid with taurine, and is widely utilized as a biochemical tool in membrane biology and protein research. Owing to its amphipathic properties, it effectively solubilizes lipid bilayers and facilitates the extraction and isolation of membrane-associated proteins, including those localized to the inner mitochondrial membrane, while preserving functional integrity under controlled conditions. In addition to its detergent function, taurodeoxycholate exhibits modulatory effects on cellular signaling pathways associated with inflammatory responses, including attenuation of pro-inflammatory mediator production, and has been investigated in models of cellular stress and neurobiology for its capacity to influence pathways linked to apoptosis and mitochondrial function. Reported bioactivity is typically observed in the nanomolar to micromolar concentration range depending on the experimental system and assay conditions. This compound is commonly employed in in vitro cell-based assays, subcellular fractionation protocols, and mechanistic studies of membrane protein dynamics, with dosing and concentration parameters varying according to specific experimental objectives and model systems.