O6-Methyl-GTP
O6-Methyl-GTP is a nucleoside triphosphate based on guanine, in which a methyl modification is introduced at the O6 position. It serves as a type of modified monomeric building block for nucleic acid synthesis. In in vitro transcription or in vitro DNA/RNA synthesis systems, it can be recognized by polymerases as a GTP analogue and incorporated into nucleic acid chains, enabling the preparation of DNA or RNA molecules containing O6-methylguanine residues. This compound is commonly used to study DNA damage and repair (particularly alkylation damage and the MGMT repair pathway), alterations in base-pairing properties, and mechanisms of gene mutation. In addition, O6-Methyl-GTP can be used to construct functional nucleic acid probes, to mimic drug action targets, or to develop novel nucleic acid materials.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 537.2 (free acid) |
| Cas No. | 99404-63-4 (free acid) |
| Formula | C11H18N5O14P3 (free acid) |
| Synonyms | O6-Methylguanosine-5'-Triphosphate |
| Chemical Name | lithium (5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | OC1C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)OC(N2C=NC3=C2N=C(N)N=C3OC)C1O.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
