Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA3413 viFSP1Summary: viFSP1 is a species-independent inhibitor that induces iron death (ferroptosis) in FSP1-dependent cells. - BA3414 UAMC-3203Summary: UAMC-3203 is a potent, selective inhibitor.
- BA3415 FSEN1Summary: FSEN1 is a potent noncompetitive inhibitor.
- BA3418 icFSP1Summary: icFSP1 is a potent inhibitor of iron death-inhibiting protein-1.
- BA3419 DB0614Summary: DB1113 is a bifunctional compound targeting protein kinase degradation.
- BA3420 GPX4-IN-5Summary: GPX4-IN-5 is a covalent inhibitor.
- BA3421 W1131Summary: W1131 is a potent inhibitor that triggers iron death.
- BA3423 SRS11-92Summary: SRS11-92, a Ferrostatin-1 (Fer-1) analog, is a potent inhibitor of iron death.
- BA3424 DB1113Summary: DB1113 is a bifunctional compound that targets protein kinase degradation.
- BA3425 Ferroptosis-IN-6Summary: Ferroptosis-IN-6 is a potent inhibitor.