DNL343
Catalog No.
BA4098
DNL343 is a brain-permeable activator of activated eukaryotic initiation factor 2B (eIF2B).
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DNL343 is a brain-permeable activator of activated eukaryotic initiation factor 2B (eIF2B) that inhibits aberrant integrative stress response (ISR).DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation.DNL343 also prevents motor dysfunction in mutant mice with a loss-of-function (LOF) mutant of eIF2B and premature death.DNL343 has inhibitory potential in studies of white matter disappearance disease (VWMD) driven by eIF2B LOF and chronic ISR activation.
| Storage | -20°C |
| M.Wt | 457.83 |
| Cas No. | 2278265-85-1 |
| Formula | C20H19ClF3N3O4 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |