Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA1184 TerreinSummary: Terrein is a melanogenesis inhibitor. - BA1192 MonactinSummary: Monactin is an antibiotic and a non-selective ion carrier for monovalent cations (including potassium, sodium and lithium).
- BA1210 AVN-944Summary: AVN-944 (VX-944) is an orally effective, selective, non-competitive and specific inhibitor of (inosine monophosphate dehydrogenase).
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BA1221 LycorineSummary: Lycorine is a naturally occurring alkaloid extracted from plants in the family Staphylinidae. -
BA1223 ErianinSummary: Erianin is commonly used as an antipyretic and pain reliever. - BA1240 GW779439XSummary: GW779439X, a pyrazolopyridine analog, is a Staphylococcus aureus PASTA kinase inhibitor.
- BA1241 PyraclostrobinSummary: Pyraclostrobin is a highly effective broad-spectrum fungicide, Pyraclostrobin induces oxidative DNA damage, mitochondrial dysfunction and autophagy through activation/signaling pathways.
- BA1242 LysozymeSummary: Lysozyme (EC 3.2.1.17) is a component of the innate immune system produced in animals.
- BA1244 AcetylshikoninSummary: Acetylshikonin is an orally effective anticancer, anti-inflammatory, antioxidant, antifertility, bacteriostatic and neuroprotective agent.
- BA1246 DeoxyshikoninSummary: Deoxyshikonin increases HMVEC-dLy neutralizing mRNA expression, promotes HIF-1α and HIF-1β subunit interactions, and binds to specific DNA sequences.