Urotensin II (114-124, human) TFA
Human Urotensin II is a neurohormone-like peptide with broad and well-characterized biological activities. It acts as a potent endogenous agonist of the UT receptor (GPR14), exhibiting an EC₅₀ of 0.1 nM for receptor binding and an EC₅₀ of 0.62 ± 0.17 nM for calcium mobilization in HEK-293 cells. Its vasoactive properties display marked species and tissue specificity: in rat thoracic aorta, it induces strong vasoconstriction with an EC₅₀ of 1.13 ± 0.36 nM, whereas in human small pulmonary arteries and mesenteric resistance arteries, it exerts potent vasodilatory effects, with pIC₅₀ values of 10.4 ± 0.5 (approximately 3.98 pM) and 10.3 ± 0.7 (approximately 5.01 pM), respectively, and maximal relaxation efficacy ranging from 81% to 96%. In non-human primates such as cynomolgus monkeys, its vasoconstrictive potency is 28-fold greater than that of endothelin-1, making it one of the most powerful mammalian vasoconstrictors known. Additionally, Human Urotensin II promotes the proliferation of human dermal fibroblasts at an optimal concentration of 10 nM, an effect that can be inhibited by pathway-specific inhibitors. It also exhibits profibrotic, neuroendocrine regulatory, and potent pro-inflammatory activities, including the induction of inflammatory cytokines such as TNF-α and IL-1β.
| Storage | -20℃, sealed storage, away from light |
| M.Wt | 1388.57 (free base) |
| Cas No. | 251293-28-4 (free base) |
| Formula | C64H85N13O18S2 • XCF3COOH |
| Synonyms | hU II |
| Chemical Name | L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5→10)-disulfide, trifluoroacetate salt |
| SDF | Download SDF |
| Canonical SMILES | [H]N[C@@H](CCC(O)=O)C(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C2=O)CC3=CC=C(O)C=C3)=O)=O)CC4=CNC5=C4C=CC=C5)=O)CC6=CC=CC=C6)=O)CSSC[C@H](N2)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O) |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
