Guanosine-5'-triphosphate disodium salt
Guanosine-5'-triphosphate disodium salt (CAS 56001-37-7) is a vital bioactive molecule involved in cellular signaling and metabolism. As a key activator in G protein-coupled receptor pathways, it regulates effector enzyme activity and participates in second messenger mechanisms through its conversion to GDP by GTPases. GTP serves as a high-energy precursor in the biosynthesis of DNA and RNA, supports transcription and DNA replication, and provides energy for protein synthesis and gluconeogenesis via the citric acid cycle. Notably, GTP upregulates miR133a, miR133b, and myogenic regulatory factors, stimulating human myogenic precursor cells to release guanosine-containing exosomes and promoting myogenic differentiation. These properties highlight its significant potential in biosynthesis and skeletal muscle regeneration research.
Reference:
1. Ohta, T., Sarkar, S., and Thach, R.E. The role of guanosine 5'-triphosphate in the initiation of peptide synthesis. lll. Binding of formylmethionyl-tRNA to ribosomes. Proc. Nat. Acad. Sci. USA 58(4), 1638-1644 (1967).
2. Hanson, R.W. and Garber, AJ. Phosphoenolpyruvate carboxykinase. l. its role in gluconeogenesis. Am.」. Clin. Nutr. 25(10), 1010-1021 (1972).
3. Neer, E.J. G proteins: Critical control points for transmembrane signals. Protein Sci. 3(1), 3-14 (1994).
4. Pietrangelo T, et al. Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine. Front Pharmacol. 2018 Mar 16;9: 152.
| Storage | Store at -20°C away from light. |
| M.Wt | 567.14 |
| Cas No. | 56001-37-7 |
| Formula | C10H14N5Na2O14P3 |
| Synonyms | 5'-GTP disodium salt |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥48.2 mg/mL in H2O |
| Chemical Name | sodium (((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid |
| SDF | Download SDF |
| Canonical SMILES | O=C1NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O)(O[Na])=O)(O)=O)(O[Na])=O)[C@@H](O)[C@H]3O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
