GTP 14564

GTP 14564 (CAS No.: 34823-86-4) is a bioactive small molecule widely utilized in biomedical research as both a functional modulator of GTP-dependent signaling and a selective inhibitor of class III receptor tyrosine kinases, including c-Fms, c-Kit, FLT3 with internal tandem duplication, and PDGFRβ. Originally characterized as a guanosine triphosphate analog, it serves as a molecular probe to investigate GTP-binding proteins and GTPase-regulated signaling pathways, where it can competitively influence nucleotide binding and modulate the activation state of intracellular signaling proteins involved in cell growth, differentiation, and protein synthesis. In parallel, GTP 14564 exhibits inhibitory activity against FLT3-driven signaling, suppressing ligand-dependent proliferation of leukemia cells such as Ba/F3 through blockade of downstream STAT5 activation, highlighting its relevance in hematologic malignancy research. Its kinase inhibitory potency is typically observed in the submicromolar to low micromolar range, with selectivity over non-receptor tyrosine kinases and serine/threonine kinases, making it a valuable tool for dissecting receptor-specific signaling mechanisms. Consequently, GTP 14564 is broadly applied in studies of signal transduction, oncogenic kinase function, and targeted drug discovery, with experimental concentrations varying according to specific cellular systems and assay conditions.