Docetaxel
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata). As an antineoplastic agent, docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization, resulting in cell cycle arrest at mitosis and subsequent apoptosis. In both in vitro and in vivo studies, docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types, such as breast, lung, ovarian, head and neck, and gastric cancers. Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel, cisplatin, and etoposide, indicating substantial research value in oncology programs.
Reference
N Katsumata. Docetaxel: an alternative taxane in ovarian cancer. British Journal of Cancer (2003) 89 (Suppl 3), S9-S15
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- 2. Schwartz, Hannah, et al. "In vitro Methods to Better Evaluate Drug Responses in Cancer." UMass Chan Medical School. September 8, 2022.
- 3. Weibo Zhong, Kaihui Wu, et al. "Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-κB-IL6-STAT3 axis." Microbiome. 2022 Jun 16;10(1):94. PMID: 35710492
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| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 807.88 |
| Cas No. | 114977-28-5 |
| Formula | C43H53NO14 |
| Synonyms | Taxotere, Docetaxel anhydrous, Trihydrate |
| Solubility | ≥40.4 mg/mL in DMSO; insoluble in H2O; ≥94.4 mg/mL in EtOH |
| SDF | Download SDF |
| Canonical SMILES | O=C(N[C@H]([C@H](C(O[C@H]1C[C@]2(O)C(C)(C)C([C@@H](O)C([C@@]3(C)[C@]([C@@](CO4)(OC(C)=O)[C@@]4([H])C[C@@H]3O)([H])[C@@H]2OC(C5=CC=CC=C5)=O)=O)=C1C)=O)O)C6=CC=CC=C6)OC(C)(C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Nine human gastric cancer cell lines |
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Preparation method |
The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 °C for several months. |
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Reaction Conditions |
< 0.00012 ~ > 1.2 μM |
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Applications |
The cytotoxic effect of Docetaxel was relatively greater than that of Paclitaxel in six of the nine cells. The effect of Docetaxel and Paclitaxel on MM-7 and ST-SA-I cells was less than on the other seven cultured cells. |
| Animal experiment [1]: | |
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Animal models |
Mice bearing human gastric cancer xenografts (MKN-28, MKN-45 and KKLS) |
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Dosage form |
3.75, 7.5, 15 or 22 mg/kg; i.v.; three times within a 4-day interval |
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Applications |
Docetaxel dose-dependently inhibited tumour growth. At the doses of 15 and 22 mg/kg, Docetaxel induced complete tumor regression in all mice. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Tanaka M, Obata T, Sasaki T. Evaluation of antitumour effects of docetaxel (Taxotere) on human gastric cancers in vitro and in vivo. Eur J Cancer. 1996 Feb;32A(2):226-30. |
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| Description | Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. | |||||
| Targets | Microtubules | |||||
| IC50 | ||||||
Quality Control & MSDS
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