Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA6455 HirsutenoneSummary: Hirsutenone, an active diheptanone contained in alder, has a variety of biological activities including anti-inflammatory, anti-tumor and anti-atopic dermatitis. - BA6501 NedometinibSummary: Nedometinib is a tyrosine kinase inhibitor that is targeted.
- BA6511 VNPP433-3βSummary: VNPP433-3β is a molecular gel degrader that targets androgen receptor and its splice variants and serine/threonine protein kinases that interact with MAP kinase.
- BA6516 DarizmetinibSummary: An inhibitor of mitogen-activated protein kinase kinase.
- BA6520 N-FeruloyloctopamineSummary: N-Feruloyloctopamine is an antioxidant ingredient.
- BA6525 CyclocurcuminSummary: Cyclocurcumin is a potent inhibitor.
- BA6541 AD57Summary: A multikinase inhibitor with oral activity.
- BA6555 GboxinSummary: Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets and inhibits glioblastoma growth.
- BA6590 AnnonacinSummary: Annonacin is an acetogenin that is toxic by inhibiting the mitochondrial complex pathway.
- BA6594 14-DeoxyandrographolideSummary: 14-Deoxyandrographolide is a laudanolic diterpene with calcium channel blocking activity.