Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA2937 ZINC69391Summary: ZINC69391 is a specific inhibitor that interferes with the Rac1-GEF interaction by masking the Trp56 residue on the Rac1 surface. - BA2938 STAT3-IN-11Summary: STAT3-IN-11(7a) is a selective inhibitor of site-specific phosphorylation.
- BA2939 NeriifolinSummary: Neriifolin is a cardiac glycoside that penetrates the central nervous system and is a depressant.
- BA2940 TP-472Summary: TP-472 is a BRD9 and BRD inhibitor.
- BA2942 LCH-7749944Summary: LCH-7749944 (GNF-PF-2356) is a potent inhibitor.
- BA2943 BAY1082439Summary: BAY1082439 is an orally active, selective inhibitor.
- BA2944 SEL24-B489Summary: SEL24-B489 is a potent, type I, orally effective dual inhibitor.
- BA2945 FamitinibSummary: Famitinib (SHR1020) is a potent, orally active multi-targeted kinase inhibitor.
- BA2946 TebufenozideSummary: Tebufenozide is a non-steroidal exocrine agonist used for pest control.
- BA2947 DidesmethylrocaglamideSummary: Didesmethylrocaglamide is a derivative of Rocaglamide and a potent inhibitor of eukaryotic initiation factor 4A.