Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA2924 AK-778-XXMUSummary: AK-778-XXMU is a potent inhibitor of DNA binding 2 antagonists. - BA2925 RX-3117Summary: RX-3117 (TV-1360) is a potent orally active anticancer and antimetabolite agent.
- BA2926 PDK4-IN-1Summary: PDK4-IN-1 is an anthraquinone derivative and a potent, orally active inhibitor of pyruvate dehydrogenase kinase 4.
- BA2928 STAT3-IN-3Summary: STAT3-IN-3 is a potent and selective inhibitor with antiproliferative activity.
- BA2929 Thalidomide-NH-CH2-COOHSummary: Thalidomide-NH-CH2-COOH is a Thalidomide-based, ligand that recruits CRBN proteins.
- BA2930 CearoinSummary: Enhances autophagy and induces apoptosis by promoting the production and activation of...
- BA2931 CipepofolSummary: Cipepofol (Ciprofol) is a novel 2,6-disubstituted phenol derivative that is a direct agonist and orthosteric modulator of receptors.
- BA2932 alpha-BisabololSummary: alpha-Bisabolol is an orally active sesquiterpene alcohol that induces cell cycle arrest, mitochondrial apoptosis and inhibits signaling pathways.
- BA2934 ThienopyridoneSummary: Thienopyridone is a potent and selective inhibitor of hepatic regenerative phosphatase phosphatase.
- BA2935 STM3006Summary: STM3006 is a potent, selective, orally active inhibitor.