Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA2898 LCS3Summary: LCS3 is a reversible and non-competitive inhibitor of glutathione disulfide reductase and thioredoxin reductase 1 (3.3 μM and 3.8 μM, respectively). -
BA2899 MY-1076Summary: MY-1076 is an inhibitor. - BA2902 PonicidinSummary: Ponicidin (RubescensineB) is a diterpene derived from dong quai with immunomodulatory, anti-inflammatory, antiviral and anticancer properties.
- BA2903 SCR130Summary: SCR130 is an SCR7-based inhibitor of DNA non-homologous end joining.
- BA2904 RO8994Summary: A potent and selective MDM2 inhibitor with IC50 of nM (HTRF binding assay) and 20 nM (MTT proliferation assay).
- BA2906 PicrocrocinSummary: Picrocrocin, a carotenoid found in saffron.
- BA2908 KaranjinSummary: Karanjin is an orally active furanoflavonoid that can be isolated from several legumes.
- BA2909 NSC49652Summary: NSC49652 is a reversible, orally active (p75, also known as NGFR, TNFRSF16 and CD271) agonist.
- BA2910 HelichrysetinSummary: Helichrysetin can be isolated from the flowers.
- BA2911 IrigeninSummary: Irigenin is a lead compound that mediates its anti-metastatic effects by specifically and selectively blocking the ExtraDomainA (EDA) domain on the C-C loop and at integrin binding sites.