Taurocholic Acid (sodium salt)
Taurocholic Acid Sodium (CAS 145-42-6) is a bile salt compound and the taurine-conjugated form of cholic acid. It participates in bile acid metabolism and the enterohepatic circulation, regulates liver function, bile secretion, and intestinal homeostasis, and is commonly used in experiments related to the physiological and pathological mechanisms of the hepatobiliary system. Its action is associated with the regulation of vascular endothelial growth factor (VEGF-A)-related signaling pathways. In animal model experiments, Taurocholic Acid Sodium improves biliary tract tissue injury caused by hepatic artery ligation by upregulating VEGF-A expression. In addition, Taurocholic Acid Sodium is also used to explore mechanisms related to inflammatory responses and immune cell function.
Endogenous levels of Taurocholic Acid Sodium are altered in association with gastrointestinal and hepatobiliary diseases and can serve as a biomarker in disease-related research.
Retrograde pancreatic duct injection of Taurocholic Acid Sodium induces a rat model of severe acute pancreatitis (SAP), used for mechanistic research on acute pancreatitis and drug evaluation.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 537.68 |
| Cas No. | 145-42-6 |
| Formula | C26H44NNaO7S |
| Synonyms | Ethanesulfonic Acid; TCA; Taurocholic acid sodium |
| Solubility | ≥117.2 mg/mL in DMSO; insoluble in EtOH; ≥57.1 mg/mL in H2O |
| Chemical Name | sodium 2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonate |
| Canonical SMILES | O[C@@H]1C[C@]2([H])C[C@H](O)CC[C@]2(C)[C@]3([H])[C@]1([H])[C@@](CC[C@]4([H])[C@@H](CCC(NCCS([O-])(=O)=O)=O)C)([H])[C@]4(C)[C@@H](O)C3.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
