Taurocholic acid
Taurocholic acid (N-Choloyltaurine) is a conjugated bile acid formed by the coupling of bile acids and taurine in the liver. It possesses both the liposoluble steroid skeleton and the polar sulfonic acid group of taurine, and exists in bile in ionic form. It has significant biological activity: In the biliary tract injury model induced by hepatic artery ligation, TCA can promote angiogenesis and tissue repair at the injury site by up-regulating the expression of vascular endothelial growth factor A (VEGF-A), and inhibit the apoptosis and fibrosis process of bile duct epithelial cells; In terms of immune regulation, TCA can regulate the polarization state of macrophages by activating bile acid receptors (such as FXR and TGR5), inhibit the release of pro-inflammatory factors (such as TNF-α and IL-6), and regulate the differentiation of T cell subsets, playing a bidirectional regulatory role in liver inflammation and systemic immune responses. As a core molecule of the bile acid metabolic network, its abnormal level is associated with diseases such as cholestatic liver disease and metabolic syndrome.
| Physical Appearance | A solid |
| Storage | Store at -20°C for 3 years. |
| M.Wt | 515.7 |
| Cas No. | 81-24-3 |
| Formula | C26H45NO7S |
| Synonyms | N-Choloyltaurine |
| Solubility | ≥25.75 mg/mL in DMSO; insoluble in EtOH; ≥51.3 mg/mL in H2O |
| Chemical Name | 2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1CC[C@@]2(C)[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(O)(=O)=O)=O)([H])C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
