Oxyresveratrol

Oxyresveratrol (CAS No.: 29700-22-9) is a naturally occurring polyphenolic compound and structural analog of resveratrol, predominantly isolated from mulberry species, and is widely studied for its antioxidant, antiviral, and neuroprotective properties in biomedical research. It functions as a potent free radical scavenger, effectively neutralizing reactive oxygen and nitrogen species, including DPPH, hydrogen peroxide, and nitric oxide, with activity observed in the low micromolar range, supporting its role in oxidative stress-related disease models. Mechanistically, oxyresveratrol acts as a noncompetitive inhibitor of tyrosinase, a key enzyme in melanogenesis, demonstrating strong inhibitory activity against mushroom tyrosinase and cellular models, thereby making it a valuable tool for studies on pigmentation disorders and enzymatic regulation. In addition, it exhibits antiviral activity against herpes simplex virus types 1 and 2 as well as varicella-zoster virus, indicating potential utility in antiviral drug discovery. Preclinical investigations further highlight its neuroprotective effects, including attenuation of apoptosis-related pathways such as cytochrome c release and caspase-3 activation, and reduction of ischemic brain injury in animal models. Oxyresveratrol is therefore broadly applied in studies of oxidative stress, neurodegeneration, viral infection, and melanogenesis, with experimental concentrations or dosing regimens varying depending on specific in vitro or in vivo research designs.