FeTPPS

FeTPPS (CAS No.: 90384-82-0) is a ferric porphyrin-based peroxynitrite decomposition catalyst widely used in biomedical research to investigate nitrosative and oxidative stress pathways, particularly in the context of neurodegenerative conditions and tissue injury. Functionally, FeTPPS acts as a potent peroxynitrite scavenger by catalyzing its isomerization to nitrate, thereby reducing intracellular nitrative stress and limiting damage to proteins, lipids, and DNA. This activity confers cytoprotective effects, with reported efficacy in the low micromolar range in cellular systems, and is associated with attenuation of nitric oxide-mediated signaling and suppression of apoptosis without directly interacting with nitric oxide or superoxide. Through modulation of reactive nitrogen species, FeTPPS is commonly employed to dissect the role of peroxynitrite in cellular signaling cascades, mitochondrial dysfunction, and inflammatory responses. In vitro and in vivo studies, including models of spinal cord and neuronal injury, utilize this compound to evaluate mechanisms of neuroprotection and to validate therapeutic strategies targeting nitrosative stress pathways, with experimental concentrations or dosing regimens varying according to specific study designs and biological contexts.