Garcinone D

Garcinone D (CAS No.: 107390-08-9) is a naturally derived xanthone isolated from Garcinia mangostana, widely investigated for its multifunctional roles in cellular signaling and disease-related pathways. This bioactive compound has been shown to modulate key regulatory networks involved in cell proliferation and oxidative stress responses, notably acting as an activator of STAT3/Cyclin D1 and Nrf2/HO-1 signaling while concurrently inhibiting CDK2/Cyclin E1 activity at low micromolar levels. Through these mechanisms, Garcinone D promotes neural stem cell proliferation, including in C17.2 cell models, by enhancing STAT3 phosphorylation and upregulating Cyclin D1 expression, alongside activation of cytoprotective antioxidant pathways mediated by Nrf2 and heme oxygenase-1. In parallel, its inhibitory effect on CDK2/Cyclin E1 contributes to cell cycle arrest in tumor cells, supporting its relevance in cancer biology research, particularly in studies involving prostate and breast cancer models. As such, Garcinone D is positioned as a valuable tool compound for investigating the interplay between stem cell biology, redox homeostasis, and cell cycle regulation, with applications in drug discovery and mechanistic studies where experimental concentrations are tailored to specific assay systems. For optimal stability, the product should be stored in a sealed container under cool and dry conditions.