Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA3007 MPT0B392Summary: MPT0B392 is an orally active quinoline derivative that is an activator. - BA3008 Thalidomide-O-C8-COOHSummary: Thalidomide-O-C8-COOH is a Thalidomide-based, ligand that recruits CRBN proteins.
- BA3009 WYC-209Summary: WYC-209, a synthetic retinoid, is a retinoic acid receptor agonist.
- BA3010 ASK1-IN-2Summary: ASK1-IN-2 is a potent, orally active inhibitor of apoptosis signal-regulated kinase 1.
- BA3011 SC99Summary: SC99 is an orally potent, selective inhibitor targeting the JAK2-STAT3 pathway.
- BA3012 SU11652Summary: SU11652 is a potent tyrosine kinase receptor inhibitor.
- BA3013 FasnallSummary: Fasnall is a selective fatty acid synthase inhibitor.
- BA3014 FalcarindiolSummary: Falcarindiol is an orally active polyacetylene oxylate that activates and increases the expression of the cholesterol transporter protein ABCA1 in cells.
- BA3015 ARD-61Summary: ARD-61 is a potent and specific androgen receptor degrader.
- BA3016 PinoresinolSummary: Pinoresinol is a plant-derived lignan used for defense in caterpillars.