Apoptosis
Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.
Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.
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BA2723 AZD-7648Summary: AZD-7648 is a selective and orally effective inhibitor. - BA2724 ICG-001Summary: ICG-001 specifically binds CREB protein to act.
- BA2725 C188-9Summary: C188-9 (TTI-101) is an inhibitor.
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BA2726 dBET6Summary: dBET6 is a highly efficient, selective, cell-permeable, ligand- and ligand-linked PROTAC. - BA2727 L-AsparaginaseSummary: L-Asparaginase (L-ASNase) is a deamidase that catalyzes the hydrolysis of L-asparagine and L-glutamine and can be used in acute lymphoblastic leukemia.
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BA2728 FB23-2Summary: FB23-2 is a potent and selective inhibitor of mRNAN-methyladenine demethylase. - BA2729 BrusatolSummary: Brusatol (NSC172924) is a unique pathway inhibitor that sensitizes a wide range of cancer cells to Cisplatin and other chemotherapeutically active molecules.
- BA2730 GSK2795039Summary: GSK2795039 is a NADPH oxidase 2 inhibitor that averaged 6 in different cell-free assays.
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BA2731 IberdomideSummary: Iberdomide (CC-220) is an orally effective (CRBN) E3 ligase modulator. - BA2732 IsoginkgetinSummary: Isoginkgetin is an inhibitor.