Disease induced
Disease-induced compounds are chemical agents used to simulate specific pathological conditions in experimental systems, such as cell cultures, organoids, or animal models.
Disease-induced compounds play a pivotal role in translational biomedical research, allowing researchers to reproduce key features of human diseases under controlled conditions, enabling the study of disease mechanisms and the testing of therapeutic interventions. For example, neurotoxins such as MPTP are widely used to model Parkinson’s disease by selectively damaging dopaminergic neurons, while streptozotocin and alloxan are used to induce diabetes through pancreatic β-cell destruction. Similarly, agents like carbon tetrachloride, bleomycin, and lipopolysaccharide are utilized to reproduce hepatic injury, pulmonary fibrosis, and systemic inflammation, respectively.
Through the application of disease-induced compounds, researchers can bridge the gap between basic molecular research and translational medicine. Their use facilitates the elucidation of disease mechanisms and supports the rational design and preclinical testing of novel therapeutic agents.
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C8731 Acetylsalicylic acid lithiumSummary: An orally active, irreversible cyclooxygenase (COX-1 and COX-2) inhibitor, also commonly used to induce gastric ulcer models. -
C8732 N,N'-DinitrosopiperazineSummary: Commonly used to induce esophageal cancer models -
C8733 N-Ethyl-N-nitrosoureaSummary: A potent DNA alkylating agent commonly used to induce and establish animal tumor models -
N2886 Kainic acid monohydrateSummary: Commonly used to establish neurodegenerative disease models -
N2887 Okadaic acid sodiumSummary: A serine/threonine protein phosphatase (PP) inhibitor, commonly used to induce cell cycle arrest and apoptosis. -
C8736 N-(6-Maleimidocaproyloxy)succinimideSummary: A heterobifunctional crosslinker commonly used in biomedical research -
C8737 AmiodaroneSummary: Antiarrhythmic drug -
C8738 N-Butyl-N-(4-hydroxybutyl)nitrosamineSummary: Commonly used to induce bladder cancer in animal models -
C8739 AAFSummary: Mainly used to induce animal models for hepatocellular carcinoma (HCC) and multiple primary tumors -
C8740 Collagen, Type II, from bovine snout membraneSummary: A collagen that plays an important role in the structure and function of skin, bones, tendons, etc.