8-Epidiosbulbin E acetate

8-epi-Diosbulbin E acetate (CAS No.: 91095-48-6) is a furan compound isolated from Dioscorea bulbifera L., and is mainly used in biomedical research to investigate its plasmid-curing activity against multidrug-resistant bacteria. Studies have shown that this compound exhibits broad-spectrum plasmid-curing effects against various multidrug-resistant bacteria, including vancomycin-resistant enterococci, with curing efficiencies ranging from 12% to 64%, depending on the bacterial species and experimental conditions. In cell models, 8-epi-Diosbulbin E acetate enhances antibiotic efficacy by reducing the minimum inhibitory concentration (MIC) of antibiotics against resistant strains. In animal model studies, this compound has been used to evaluate its hepatotoxic effects; results indicate it can induce liver injury in mice, suggesting that potential hepatotoxicity risks should be considered during drug development. The doses or concentrations used in experiments typically depend on the experimental design and research objectives.