Tetraxetan

Tetraxetan (CAS No.: 60239-18-1) is 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA), widely used in the biopharmaceutical field, mainly as a metal chelator for radiolabeling with radioisotopes and for the preparation of contrast agents. Its strong multidentate coordination ability enables it to stably chelate a variety of metal ions, such as lanthanides and transition metals, forming stable metal complexes. These complexes are used in medical imaging for diagnostic techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), and in radionuclide therapy as carriers for radiopharmaceuticals. In in vitro studies, Tetraxetan-derived metal complexes exhibit activity levels in the nanomolar to micromolar range, with specific activity depending on the chelated metal ion and the target molecule. In cellular and animal models, these complexes are often used for imaging and therapeutic research targeting tumor cells, and the doses or concentrations used in experiments typically depend on the experimental design and research objectives. Due to its excellent metal-chelating performance and biocompatibility, Tetraxetan has important application value in drug development and molecular imaging research.