Taurolithocholic Acid MaxSpec® Standard
Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acid. TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells. It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.
The TLCA standard is a quantitative grade standard specifically prepared for mass spectrometry and related applications requiring quantitative reproducibility. This TLCA standard is guaranteed to meet specifications for identity, purity, stability, and concentration.
| Storage | Store at -20°C |
| M.Wt | 483.71 |
| Cas No. | 516-90-5 |
| Formula | C26H45NO5S |
| Synonyms | Taurolithocholic acid, NSC 681057, TLCA |
| Solubility | Soluble in DMSO |
| Chemical Name | 2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C(NCCS(O)(=O)=O)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
