Metabolism


Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
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C8956 Oxolamine CitrateSummary: Oxolamine Citrate is a synthetic non-opioid antitussive compound used as a reference standard in pharmacological, analytical, and respiratory pathway research. -
C8961 Dipivefrin HydrochlorideSummary: Dipivefrin Hydrochloride is an adrenergic prodrug and nonselective alpha/beta receptor agonist used to investigate catecholaminergic signaling in ophthalmic pharmacology and receptor biology research. -
C8966 Setmelanotide (RM-493)Summary: Setmelanotide (RM-493) is a selective melanocortin-4 receptor agonist used to investigate melanocortin signaling pathways in metabolic and neuroendocrine research. -
C8969 (R)-AvanafilSummary: (R)-Avanafil is a selective phosphodiesterase type 5 inhibitor targeting the cGMP signaling pathway, widely utilized as a reference compound in vascular biology research. -
C8973 Bremelanotide AcetateSummary: Bremelanotide Acetate is a synthetic melanocortin receptor agonist targeting MC3R and MC4R, widely utilized in neuroendocrine signaling and receptor pharmacology research. -
C8986 Naloxegol OxalateSummary: Naloxegol Oxalate is a peripherally selective μ-opioid receptor antagonist used to investigate opioid receptor signaling and gastrointestinal motility mechanisms in pharmacological research. -
C8987 Clocortolone PivalateSummary: Clocortolone Pivalate is a synthetic corticosteroid glucocorticoid receptor agonist used as a reference compound in steroid signaling and inflammation-related molecular research. -
BA7918 CirsiliolSummary: Cirsiliol is a potent and selective inhibitor of 5-lipoxygenase. -
BA7927 5-LOX-IN-2Summary: 5-LOX-IN-2 is a 5-lipoxygenase inhibitor. -
BA7948 YamogeninSummary: Yamogenin (Neodiosgenin) is the diastereoisomer of Diosgenin.
