1,2-Dimyristoyl-sn-glycero-3-PC

1,2-Dimyristoyl-sn-glycero-3-PC (CAS No.: 18194-24-6) is a well-characterized synthetic phosphatidylcholine widely employed as a model membrane lipid in biophysical, biochemical, and pharmaceutical research. As a zwitterionic phospholipid, it readily forms stable lipid monolayers and bilayers, making it particularly valuable for constructing liposomes and artificial membrane systems that recapitulate key structural and dynamic features of biological membranes. This compound is extensively used to investigate membrane organization, phase behavior, and lipid–protein interactions, providing a controlled platform for studying membrane protein function, membrane fluidity, and lipid-mediated signaling processes. In drug discovery and delivery research, it serves as a foundational component in liposomal formulations and nanocarriers, facilitating the evaluation of drug encapsulation, release kinetics, and membrane permeability. Additionally, reported antiproliferative effects in tumor cell models suggest that its biological activity may involve modulation of membrane integrity or lipid-associated signaling pathways, although specific molecular targets remain incompletely defined. In vitro studies typically employ concentrations in the micromolar range depending on the experimental system, and its applications span cell-based assays, biophysical membrane studies, and preclinical formulation development, with dosing and usage tailored to specific research objectives.