8-Azido-ATP
Catalog No.
B8032
Base modified ribonucleoside triphosphates
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8-Azido-ATP is a ribonucleoside triphosphate analog with an azido group substitution at the adenine C-8 position. It acts primarily as an ATP mimic, interacting with poly(A) polymerase (PAP), specifically illustrated using yeast poly(A) polymerase (yPAP). Incorporation of 8-azido-ATP into growing polyadenylation chains results in premature termination and moderately shorter poly(A) tails relative to natural ATP substrates. Due to its chain-terminating capacity and altered substrate specificity, 8-azido-ATP is applied in biochemical studies examining enzyme fidelity, nucleotide selection mechanisms, and RNA polymerase activity.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 548.2 (free acid) |
| Formula | C10H15N8O13P3 (free acid) |
| Synonyms | 8-Azidoadenosine-5'-Triphosphate |
| Chemical Name | lithium (5-(6-amino-8-azido-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | NC1=NC=NC2=C1N=C(N=[N+]=[N-])N2C3C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O3.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
