5-Br-UTP
Catalog No.
B8034
Base modified ribonucleoside triphosphates
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5-Br-UTP is a chemically modified ribonucleoside triphosphate that incorporates a bromine substituent at the 5 position of uracil. Upon enzymatic incorporation into RNA sequences, this compound confers enhanced structural stability and tolerance to enzymatic degradation by nucleases. Such modified ribonucleotides are frequently employed in SELEX (Systematic Evolution of Ligands by EXponential enrichment) methodologies to generate aptamers exhibiting improved resistance to nucleolytic cleavage and greater thermal robustness. Consequently, 5-Br-UTP holds relevance for RNA-based therapeutic research and aptamer engineering applications.
| Physical Appearance | Solution |
| Storage | Store at -20°C or below |
| M.Wt | 563.0 (free acid) |
| Formula | C9H14N2O15P3Br (free acid) |
| Synonyms | 5-Bromouridine-5'-Triphosphate |
| Chemical Name | lithium (5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C(C(Br)=CN1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = ≥90% by AX-HPLC
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
