sn-Glycerol-3-phosphate (cyclohexyl ammonium salt hydrate)

G3P is a pivotal metabolic intermediate linking glycolysis and lipid metabolism, endowed with multiple biological activities and functions. It participates in the glycerol phosphate shuttle, facilitating the transfer of NADH reducing equivalents to the oxidative phosphorylation pathway and regenerating NAD⁺. As a substrate in synthetic biology research on reactive oxygen species, G3P is utilized to assess its availability in cardiac tissues. Furthermore, it serves as a substrate for intracellular glycerol-3-phosphate acyltransferase, thereby influencing insulin production and playing a critical role in systemic acquired resistance in plants. Aberrant levels of G3P have also been associated with salivary alterations in patients with Alzheimer’s disease, frontotemporal dementia, and Lewy body dementia, underscoring its central role in lipid biosynthesis and the pathogenesis of various metabolic and neurodegenerative disorders.

References:

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