L-Leucyl-L-Leucine methyl ester (hydrochloride)

L-Leucyl-L-Leucine methyl ester (hydrochloride) (CAS No.: 6491-83-4) is a condensation product of the L-leucine methyl ester dipeptide produced by human monocytes or polymorphonuclear leukocytes, mainly used in biomedical research. This compound can selectively eliminate lymphocytes with cytotoxic potential, including natural killer cells as well as CD4? and CD8? T lymphocytes, while having less impact on helper T cells and B cells. In addition, L-Leucyl-L-Leucine methyl ester (hydrochloride) can induce lysosomal pathway stress, affecting the function and stability of intracellular lysosomes. In vitro studies show that this compound can enhance LRRK2 (leucine-rich repeat kinase 2)-mediated Rab10 and Rab12 phosphorylation, suggesting a potential role in cellular signal transduction and protein regulation. The dose or concentration used in experiments typically depends on the experimental design and research objectives. This compound is commonly used in cell and animal models to study its effects on immune cell function, lysosomal stress responses, and related signaling pathways, providing an important tool for immunology and cell biology research.