Hyocholic Acid
Hyocholic Acid is a bile acid first discovered in pigs, known for its unique physiological functions. In addition to being found in pigs, Hyocholic Acid can also be detected in the urine samples of patients with cholestasis, indicating its close relationship with bile metabolism and liver function. Research shows that Hyocholic Acid promotes the secretion of glucagon-like peptide-1 (GLP-1) from intestinal endocrine cells by activating the G protein-coupled receptor TGR5 and inhibiting the nuclear receptor FXR. GLP-1 is an important intestinal hormone that has been proven to play a positive role in insulin secretion, blood glucose regulation, and appetite control. Therefore, Hyocholic Acid is considered a potential anti-diabetic molecule, particularly showing promise in the prevention and treatment of type 2 diabetes. By regulating the secretion of intestinal hormones, Hyocholic Acid may offer a new therapeutic strategy for diabetes patients.
| Storage | Store at -20°C for 3 years. |
| M.Wt | 408.58 |
| Cas No. | 547-75-1 |
| Formula | C24H40O5 |
| Solubility | ≥54 mg/mL in DMSO; ≥43.9 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid |
| SDF | Download SDF |
| Canonical SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@]3([H])[C@H](O)[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
