Semaglutide
Catalog No.
C8705
GLP-1 receptor agonist
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Semaglutide is a long-acting GLP‑1 receptor agonist. Its structure is modified with a fatty acid and binds to albumin, with a half-life of about 1 week. It activates GLP‑1R on pancreatic β cells to promote glucose-dependent insulin secretion, while inhibiting glucagon from α cells, slowing gastric emptying, and acting on central appetite centers such as the hypothalamus to reduce food intake and body weight. Related pathways include cAMP/PKA, PI3K/AKT, and others. It is used for the treatment of type 2 diabetes and obesity, and cardiovascular outcomes trials have shown a reduction in MACE risk.
| Storage | -20℃, sealed storage, away from moisture and light |
| M.Wt | 4113.58 |
| Cas No. | 910463-68-2 |
| Formula | C187H291N45O59 |
| Solubility | ≥49.7 mg/mL in DMSO; insoluble in EtOH; ≥50.9 mg/mL in H2O |
| Canonical SMILES | O=C(O)CNC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CO)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC5=CC=CC=C5)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(O)=O)NC(C(NC([C@H](CC6=CNC=N6)N)=O)(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
