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Fumonisin B1

Catalog No.
A4537
PP5/PP2Cα/PP2A/PP1γ2/PP2B inhibitor
Grouped product items
SizePriceStock Qty
1mg
$146.00
Ship with 5-10 days
5mg
$648.00
Ship with 5-10 days
10mg
$819.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Fumonisin B1 (CAS 116355-83-0) is a mycotoxin isolated from the fungus Fusarium moniliforme. It potently inhibits sphingosine N-acyltransferase (ceramide synthase), an enzyme critical to sphingolipid biosynthesis, leading to the intracellular accumulation of sphingoid bases (IC?? ~75 nM). Additionally, Fumonisin B1 exhibits inhibitory activity against several protein phosphatases, notably PP5, PP2Cα, PP2A, PP1γ2, and PP2B, with IC?? ranging from approximately 80 μM (PP5) to 3000 μM (PP2B). This compound is employed in biomedical research to investigate sphingolipid metabolism, cell signaling, and phosphatase-related cellular processes.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt721.83
Cas No.116355-83-0
FormulaC34H59NO15
SolubilityLimited solubility, soluble in DMSO
Chemical Namerac-(2R,2'R)-2,2'-((((5S,6S,7R,9R,11S,16S,18R,19R)-19-amino-11,16,18-trihydroxy-5,9-dimethylicosane-6,7-diyl)bis(oxy))bis(2-oxoethane-2,1-diyl))disuccinic acid
SDFDownload SDF
Canonical SMILESC[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](OC(C[C@@H](C(O)=O)CC(O)=O)=O)[C@H](OC(C[C@@H](C(O)=O)CC(O)=O)=O)[C@H](C)CCCC
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Fumonisin B1

Related Biological Data

Fumonisin B1