Fumonisin B1|PP5/PP2Cα/PP2A/PP1γ2/PP2B inhibitor|CAS# 116355-83-0

Size	Price	Stock
1mg	$71.00	In stock
5mg	$319.00	In stock
10mg	$532.00	In stock

Publications citing ApexBio Products

Nature.
2017 Jan 19;541(7637):417-420.

Nature.
2018 Nov;563(7731):407-411.

Nature.
2018 Jun 13.

Nature.
2018 Jun 27.

Nature.
2018 Mar 29;555(7698):673-677.

Nature.
2017 Sep 7;549(7670):96-100.

Nature.
2016 Apr 21;532(7599):398-401.

Science.
2016 Aug 5;353(6299)594-8

Nat Nanotechnol.
2017 Dec;12(12):1190-1198.

Nature Biotechnology.
2017 Jun;35(6):569-576

Nat Med.
2018 Sep 17.

Cell.
2018 Dec 21. pii: S0092-8674(18)31561-7.

Cell.
Available online 25 October 2018.

Cell.
2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.
2018 Jun 28;174(1):172-186.e21.

Cell.
2018 Feb 22;172(5):1007-1021.e17.

Cell.
2017 Nov 30;171(6):1284-1300.e21.

Cell.
2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.
2017 Jul 13;170(2):312-323

Nat Med.
2018 Jan 29.

Nat Med.
2017 Nov;23(11):1342-1351.

Cell.
2017 Apr 6;169(2):286-300.

Cell.
2015 Aug 27;162(5):987-1002.

Cell.
2015 Feb 12;160(4):729-44.

Nature Medicine.
2017 Apr;23(4):493-500.

Cancer Cell.
2018 May 14;33(5):905-921.e5.

Cancer Cell.
2018 Apr 9;33(4):752-769.e8.

Cancer Cell.
2018 Mar 12;33(3):401-416.e8.

Cancer Cell.
2017 Aug 14;32(2):253-267.e5.

Nat Methods.
2018 Jul;15(7):523-526.

Cell Stem Cell.
2018 May 3;22(5):769-778.e4.

Cell Stem Cell.
2017 Nov 20. pii: S1934-5909(17)30375-2.

Quality Control

Quality Control & MSDS

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Purity ≥95.00%

Chemical structure

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Chemical Properties

Cas No.	116355-83-0	SDF	Download SDF
Synonyms	N/A
Chemical Name	2-[2-[19-amino-6-(3,4-dicarboxybutanoyloxy)-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid
Canonical SMILES	CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
Formula	C₃₄H₅₉NO₁₅	M.Wt	721.83
Solubility	Limited solubility, soluble in DMSO	Storage	Store at 4°C
Physical Appearance	A crystalline solid	Shipping Condition	Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC₅₀ ~ 75 nM). Also inhibits protein phosphatases; IC₅₀ values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.