Epiallopregnanolone
Catalog No.
C4172
inactive as a GABAA receptor modulator and used as a control substance to examine GABA neurotransmission.
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Epiallopregnanolone (CAS 567-01-1) is an endogenous neurosteroid metabolite derived from progesterone, structurally characterized as the 3β-isomer of allopregnanolone. Epiallopregnanolone functions mainly as a competitive antagonist at neurosteroid binding sites on GABA_A receptors, ligand-gated chloride channels essential for neuronal inhibition. In vitro, it selectively inhibits allopregnanolone-induced chloride ion flux and antagonizes allopregnanolone and ethanol-mediated suppression of hippocampal CA1 population spikes. In vivo experiments indicate epiallopregnanolone reduces ethanol discrimination behavior in trained rats. Its selective GABA receptor antagonism supports utility in neuroactive steroid and ethanol interaction research.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 334.5 |
| Cas No. | 567-01-1 |
| Formula | C21H34O3 |
| Synonyms | 5α-Pregnan-20-one,3β,21-dihydroxy-5α-Pregnan-20-one,3β,5α-Tetrahydrodeoxycorticosterone,3β,5α-Tetrahydroprogesterone |
| Solubility | ≤25mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide |
| Chemical Name | 3,21-dihydroxy-, (3ß,5α)-pregnan-20-one |
| SDF | Download SDF |
| Canonical SMILES | C[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@]3([H])CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
