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AVE 0991 Agonist of angiotensin-(1-7) receptor

Catalog No.B1007
Size Price Stock Qty
10mM (in 1mL DMSO)
$315.00
In stock
5mg
$238.00
In stock
10mg
$361.00
In stock
25mg
$523.00
In stock
50mg
$855.00
In stock
100mg
$1,330.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

AVE 0991

Biological Activity

Description AVE 0991 is an agonist of angiotensin-(1-7) receptor with IC50 value of 21 nM.
Targets angiotensin-(1-7) receptor          
IC50 21 nM          

Protocol

Cell experiment [1]:

Cell lines

Mas-transfected COS cells

Preparation method

The solubility of this compound in DMSO is > 29mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.

Reacting condition

10-6 M

Applications

AVE 0991 competed the specific binding of 125I-Ang-(1-7) to Mas-transfected COS cells with an IC50 value of 4.75 × 10-8 M. In addition, at the dose of 10-6 M, AVE 0991 completely abolished the specific binding of rhodamine-labeled Ang-(1-7) to Mas-transfected CHO cells.

Animal experiment [1]:

Animal models

Water-loaded WT mice (C57BL/6)

Dosage form

0.58 nmol/g; i.p.

Applications

In water-loaded WT mice (C57BL/6), AVE 0991 significantly decreased water dieresis, which was associated with an increase in urine osmolality.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Sergio Veloso Brant Pinheiro, Ana Cristina Simoes e Silva, Walkyria Oliveira Sampaio, Renata Dutra de Paula, Elizabeth Pereira Mendes, Elizabete Dias Bontempo, Joao Bosco Pesquero, Thomas Walther, Natalia Alenina, Michael Bader, Markus Bleich, Robson Augusto Souza Santos. Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney. Hypertension. 2004, 44: 490-496.

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Chemical Properties

Cas No. 304462-19-9 SDF Download SDF
Chemical Name 1-ethyl-3-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylurea
Canonical SMILES CCNC(=O)NS(=O)(=O)C1=C(C=C(S1)CC(C)C)C2=CC=C(C=C2)CN3C(=C(N=C3C4=CC=CC=C4)OC)C=O
Formula C29H32N4O5S2 M.Wt 580.72
Solubility >29mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

AVE 0991 is an agonist of angiotensin-(1-7) receptor [1].

As an ang-(1–7) mimic, AVE0991 acts as a nonpeptide agonist of angiotensin-(1-7) receptor. In water-loaded mice (C57BL/6), AVE0991(0.58 nmol/g)produces a significant decrease of water dieresis. The antidiuretic effect of AVE was associated with an increase in urine osmolality. It also occurs in water-loaded Swiss mice. The antidiuretic action of AVE can be blocked by the Ang II antagonists completely, demonstrating the specificity of AVE 0991. Since Ang II promotes atherogenesis and ang-(1–7) opposites Ang II action, it is reported that AVE 0991 can inhibit atherogenesis in apolipoprotein E (apoE)-knockout mice model [1, 2].

References:
[1] Sergio Veloso Brant Pinheiro, Ana Cristina Simoes e Silva, Walkyria Oliveira Sampaio, Renata Dutra de Paula, Elizabeth Pereira Mendes, Elizabete Dias Bontempo, Joao Bosco Pesquero, Thomas Walther, Natalia Alenina, Michael Bader, Markus Bleich, Robson Augusto Souza Santos. Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney. Hypertension. 2004, 44: 490-496.
[2] J. Toton-Zuranska, M. Gajda, G. Pyka-Fosciak, K. Kus, M. Pawlowska, A. Niepsuj, P. Wolkow, R. Olszanecki, J. Jawien, R. Korbut. AVE 0991- angiotensin-(1-7) receptor agonist, inhibits atherogenesis in APOE-knockout mice. Journal of physiology and pharmacology. 2010, 61(2):181-183.