Home >> Perindopril
Related Products
Perindopril ACE inhibitor

Catalog No.B1214
Size Price Stock Qty
100mg
$60.00
In stock
250mg
$120.00
In stock
500mg
$180.00
In stock
1g
$270.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Related Compound Libraries

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Perindopril

Perindopril Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Perindopril Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Chemical Properties

Cas No. 82834-16-0 SDF Download SDF
Chemical Name (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Canonical SMILES CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
Formula C19H32N2O5 M.Wt 368.47
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

Perindopril is an inhibitor of angiotensin-I converting enzyme (ACE) [1].

As an inhibitor of ACE, perindopril has been reported to have anticancer activity through the inhibition of tumor growth and angiogenesis in hepatocellular carcinoma cells. In the in vitro cell proliferation assays, perindopril does not show significant effect on the cell proliferation. However, even 1μM perindoprilat can significantly reduce mRNA expression of VEGF and can inhibit the induction activity of the VEGF promoter in KB cells. Also in KB cells, 1μM perindoprilat treatment significantly suppresses the angiotensin II production. Besides that, In vivo assays demonstrate perindopril can suppress the growth of SCC-VII cells [1]. Moreover, it is reported that 8 mg perindopril given orally can lower blood pressure without a change in heart rate [1, 2].

References:
[1] Ryuji Yasumatsu, Torahiko Nakashima, Muneyuki Masuda, Aya Ito, Yuichiro Kuratomi, Yuichiro Kuratomi and Shizuo Komune. Effects of the angiotensin-I converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2004, 130: 567–573.
[2] A.A.Ajayi, K.R.Lees and J.L.Reid. Effects of angiotensin converting enzyme inhibitor, perindopril, on autonomic reflexes. Eur J Clin Pharmacol. 1986, 30:177-182.