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Cy3.5 azide (non-sulfonated)

Catalog No.
A8112
used for Click chemistry to label alkyne-modified oligonucleotides
Grouped product items
SizePriceStock Qty
5mg
$460.00
In stock
25mg
$1,350.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Cy3.5 azide is a solid material dye ready for the use in Click Chemistry reaction. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer.

Cy3.5 azide could easily interfere with a radical polymerisation process as it contains a variety of double bonds. The Cy-3 modified initiator was then used to grow the modified PMPC-PDPA directly from the dye [1].

Reference:
[1] Gaitzsch, J. ; Delahaye, M.; Poma, A.; Du Prez, F.; Battaglia, G. Comparison of metal free polymer-dye conjugation strategies in protic solvents. Polymer Chemistry, 2016, 7(17), 3046–3055.

Chemical Properties

Physical AppearanceA solid
Storage24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
M.Wt717.38
FormulaC44H53ClN6O
Solubility≥71.7 mg/mL in DMSO; insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic
Chemical Name3-(6-((3-azidopropyl)amino)-6-oxohexyl)-2-((1E,3E)-3-(3-butyl-1,1-dimethyl-1H-benzo[e]indol-2(3H)-ylidene)prop-1-en-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium
SDFDownload SDF
Canonical SMILESCC1(C)C2=C3C(C=CC=C3)=CC=C2[N+](CCCCCC(NCCCN=[N+]=[N-])=O)=C1/C=C/C=C4C(C)(C)C5=C(C=CC=C6)C6=CC=C5N\4CCCC
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Spectral properties

Excitation max (nm) 591 Emission max (nm) 604
Extinction Coefficient (M-1cm-1) 116000 Quantum Yield 0.35
CF260 0.29 CF280 0.22

Quality Control

Chemical structure

Cy3.5 azide

Related Biological Data

Cy3.5 azide