Adrenic Acid

7Z,10Z,13Z,16Z-Docosatetraenoic Acid (CAS No.: 28874-58-0) is a naturally occurring polyunsaturated fatty acid derived from the elongation of arachidonic acid and widely distributed in mammalian tissues, including the adrenal gland, brain, kidney, and vascular system, where it contributes to lipid signaling and metabolic regulation. This bioactive lipid is recognized for its role in modulating vascular tone, particularly within the adrenal cortex, and for influencing enzymatic activities associated with cyclooxygenase-mediated pathways, leading to the formation of biologically active metabolites such as dihomo-prostaglandins. Through its participation in lipid mediator networks, it is implicated in the regulation of inflammatory responses and has been identified as a contributor to inflammation-associated pathologies, including non-alcoholic fatty liver disease. Mechanistically, it is associated with pathways involving eicosanoid metabolism and redox-sensitive signaling cascades, although specific molecular targets remain incompletely defined and are often inferred from its metabolic derivatives. In vitro studies typically explore its biological effects at concentrations spanning the nanomolar to low micromolar range, depending on the cell type and assay system. In biomedical research, it is commonly utilized in cell-based assays and animal models to investigate lipid metabolism, vascular physiology, and inflammation-related disorders, with dosing and experimental conditions tailored to specific study objectives in drug discovery and mechanistic research.