Recombinant Human GM-CSF

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is secreted by several different types of cells, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokines or immune and inflammatory stimuli. It was originally described as a growth factor that can support in vitro colony formation of granulocyte-macrophage progenitor cells and has the function of stimulating the growth and differentiation of hematopoietic precursor cells from different lineages. GM-CSF has also been reported to have functional effects on non-hematopoietic cells and can induce human endothelial cell migration and proliferation. In addition, it stimulates the proliferation of a variety of tumor cell lines, including osteoblastic sarcoma, carcinoma, and adenocarcinoma cell lines. Human GM-CSF and mouse GM-CSF have 54% sequence identicality, but there is no biological effect between different species. GM-CSF is used as a drug to stimulate the production of white blood cells after chemotherapy and has recently been evaluated in clinical trials as a vaccine adjuvant in HIV-infected patients.

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