PD 180970
Catalog No.
A8606
P210bcr/abl tyrosine kinase inhibitor
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ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively).
| Physical Appearance | Yellow solid |
| Storage | Store at -20°C |
| M.Wt | 429.27 |
| Cas No. | 287204-45-9 |
| Formula | C21H15Cl2FN4O |
| Solubility | <21.46mg/ml in DMSO |
| Chemical Name | 6-(2,6-dichlorophenyl)-2-(4-fluoro-3-methylanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one |
| SDF | Download SDF |
| Canonical SMILES | Cc(cc(cc1)Nc2ncc(C=C(c(c(Cl)ccc3)c3Cl)C(N3C)=O)c3n2)c1F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
