Oleic Acid

Oleic Acid (CAS No.: 112-80-1) is a naturally occurring monounsaturated fatty acid widely distributed in animal and plant-derived lipids and commonly utilized as a bioactive lipid mediator in metabolic and signaling research. It plays multifaceted roles in cellular physiology by modulating membrane composition, lipid metabolism, and signal transduction pathways, and has been shown to influence integrin-linked kinase expression as well as activate G protein-coupled receptor signaling, leading to downstream ERK1/2 phosphorylation and effects on cell proliferation in cancer models. In addition, oleic acid has been reported to modulate Na+/K+-ATPase activity and contribute to inflammatory responses, including the induction of pulmonary edema, leukocyte infiltration, lipid body formation, and increased production of eicosanoids such as leukotriene B4 and prostaglandin E2 in experimental systems. Its biological activity is typically observed in the low micromolar range in vitro, although effective concentrations vary depending on cell type and experimental context. Oleic acid is frequently employed in studies of lipid signaling, inflammation, cancer biology, and metabolic disorders, as well as in the development of cell-based assays and animal models investigating fatty acid-mediated regulatory mechanisms, with dosing and exposure conditions tailored to specific research objectives.