L-Homopropargyl Glycine
Catalog No.
C3406
reactive methionine analog for the detection of nascent protein synthesis
Featured Products
L-Homopropargyl Glycine (CAS 98891-36-2), abbreviated as Hpg, is a noncanonical amino acid structurally analogous to methionine, featuring an alkyne functional group. Upon incorporation into newly synthesized proteins during translation, Hpg enables selective labeling of nascent proteins through copper-catalyzed alkyne-azide cycloaddition ('click chemistry'). This fluorescent tagging strategy permits temporal tracking of protein synthesis dynamics in mammalian cells via pulse-chase labeling. Such a methodology facilitates direct imaging of protein translation activities, including those relevant to neuronal function and synaptic plasticity, aiding the investigation of compartment-specific protein synthesis.
- 1. Yaqiong Li, Zhipeng Niu, et al. "Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii." Nature Communications. 26 January 2023
- 2. Xuke Yang, Xiaoyan Yin, et al. "Essential role of pyrophosphate homeostasis mediated by the pyrophosphate-dependent phosphofructokinase inToxoplasma gondii." PLoS Pathog. 2022 Feb 1;18(2):e1010293. PMID: 35104280
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 127.1 |
| Cas No. | 98891-36-2 |
| Formula | C6H9NO2 |
| Synonyms | Click Tag™ L-Homopropargyl Glycine,HPG |
| Solubility | ≥2.72 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥13.8 mg/mL in H2O |
| Chemical Name | (2S)-2-amino-5-hexynoic acid |
| SDF | Download SDF |
| Canonical SMILES | C#CCC[C@H](N)C(O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
